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Hematology Quiz | Practice MCQ #mcq.ImBooz

February 11, 2020 by Dr. IM Leave a Comment

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1 >>True regarding central nervous system involvement in sickle cell disease is: ?

  • (A) Microvasculature is commonly involved
  • (B) Chronic transfusion does not help much
  • (C) Cognitive impairment is not seen
  • (D) Transcranial Doppler is helpful

2 >>True regarding sickle cell trait are all, except: ?

  • (A) Is associated with normal growth and life expectancy
  • (B) The ratio of HbA to HbS is 50:50
  • (C) Impaired urine-concentrating ability and haematuria can occur
  • (D) Splenic infarction is possible at very high altitudes

3 >>True regarding the sickling test is: ?

  • (A) Can distinguish sickle cell trait from sickle cell anaemia
  • (B) Can be used for primary diagnosis of HbSS
  • (C) Can quantify HbS
  • (D) None of the above

4 >>Hydroxycarbamide (hydroxyurea) therapy in SCD results in reduction of all, except: ?

  • (A) Acute chest syndrome
  • (B) Acute painful crises
  • (C) Leg ulcers
  • (D) All of the above

5 >>Which is not true regarding normal cell cycle? ?

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  • (A) DNA replication occurs in G1 phase
  • (B) The normal cell cycle is G1-S-G2-M
  • (C) Cdk phosphorylates the protein targets
  • (D) Cyclin proteins are formed during specific phases

6 >>Which is true regarding apoptosis? ?

  • (A) Caspases are the ultimate effectors of apoptosis
  • (B) FAS and TNF-R have an extracellular death domain
  • (C) BCL-2 is a proapoptotic protein
  • (D) Entry of cytochrome c into mitochondria is a critical step

7 >>All of the following are proapoptic proteins, except: ?

  • (A) Bax
  • (B) Bid
  • (C) Bcl-2
  • (D) Bak

8 >>All of the following are anti-apoptotic proteins, except: ?

  • (A) Bcl-X1
  • (B) Bcl-2
  • (C) Bcl-6
  • (D) None of the above

9 >>Which of the following statements is not true regarding transcription factors? ?

  • (A) Contains DNA binding and activation domain
  • (B) Helix-loop-helix is a DNA-binding domain
  • (C) c-abl gene translocation in CML, is an example
  • (D) They regulate gene expression by regulating the transcription of specific genes

10 >>Which one of these statements is not true regarding cell adhesion molecules? ?

  • (A) Chemokines are a major family
  • (B) They include the immunoglobulin superfamily
  • (C) They are important in the spread and localization of tumor cells
  • (D) Integrins can bind cells to extracellular matrix

11 >>Which one of these molecules does not have a role in the transduction pathway of growth factors? ?

  • (A) p 53
  • (B) RAS
  • (C) STAT
  • (D) JAK

12 >>Which of the following statement is not true regarding clonal abnormality in cytogenetic analysis? ?

  • (A) 2 cells with translocation, deletions or inversions signifies abnormal chromosome
  • (B) 1 cell showing loss of chromosome
  • (C) Single cell with recurring structural abnormality
  • (D) 2 cells with gain of same chromosome

13 >>All of the following are major cell cycle check points, except: ?

  • (A) DNA damage check point
  • (B) The spindle check point
  • (C) The spindle pole body duplication check point
  • (D) RNA damage check point

14 >>A 29 year old woman was found to have a Hb of 7.8 gm/dL with reticulocyte count of 0.8%. PS showed microcytic hypochronic anemia. Hb A2 and Hb F levels were 2.4% and 1.3% respectively. Serum iron and TIBC were 15 mgm/dL and 420 mgm/dL repectively. The likely diagnosis is: ?

  • (A) IDA
  • (B) ? thalassemia minor
  • (C) Sideroblastic anemia
  • (D) Anemia of chronic inflammation

15 >>A child presented with microcytic hypochromic anemia with normal levels of RBC protoporphyrin. Most likely diagnosis is: ?

  • (A) Lead toxicity
  • (B) IDA
  • (C) Thalassemia
  • (D) Anemia of chronic inflammation

16 >>Which of the following test is best suited for community based screening programme for identifying iron deficiency? ?

  • (A) Serum ferritin
  • (B) Red cell protoporphyrin level
  • (C) Serum iron
  • (D) TIBC

17 >>Which of the following test is best in differentiating between anemia of chronic inflammation and IDA? ?

  • (A) Serum ferritin
  • (B) Serum transferrin receptor
  • (C) TIBC
  • (D) Transferrin saturation

18 >>Elevated serum ferritin, serum iron and percentage transferring saturation are most consistent with diagnosis of: ?

  • (A) IDA
  • (B) Hemochromatosis
  • (C) Anemia of chronic inflammation
  • (D) Lead poisioning

19 >>Which of the following is earliest recognizable change in RBC morphology in case of iron deficiency? ?

  • (A) Hypochromia
  • (B) Anisocytosis
  • (C) Target cells
  • (D) Poikilocytosis

20 >>All of the following are causes of iron deficiency anemia, except: ?

  • (A) Chronic renal failure
  • (B) Celiac sprue
  • (C) Hookworm
  • (D) Carcinoma colon

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