1 >>True regarding central nervous system involvement in sickle cell disease is: ?
- (A) Microvasculature is commonly involved
- (B) Chronic transfusion does not help much
- (C) Cognitive impairment is not seen
- (D) Transcranial Doppler is helpful
2 >>True regarding sickle cell trait are all, except: ?
- (A) Is associated with normal growth and life expectancy
- (B) The ratio of HbA to HbS is 50:50
- (C) Impaired urine-concentrating ability and haematuria can occur
- (D) Splenic infarction is possible at very high altitudes
3 >>True regarding the sickling test is: ?
- (A) Can distinguish sickle cell trait from sickle cell anaemia
- (B) Can be used for primary diagnosis of HbSS
- (C) Can quantify HbS
- (D) None of the above
4 >>Hydroxycarbamide (hydroxyurea) therapy in SCD results in reduction of all, except: ?
- (A) Acute chest syndrome
- (B) Acute painful crises
- (C) Leg ulcers
- (D) All of the above
5 >>Which is not true regarding normal cell cycle? ?
- (A) DNA replication occurs in G1 phase
- (B) The normal cell cycle is G1-S-G2-M
- (C) Cdk phosphorylates the protein targets
- (D) Cyclin proteins are formed during specific phases
6 >>Which is true regarding apoptosis? ?
- (A) Caspases are the ultimate effectors of apoptosis
- (B) FAS and TNF-R have an extracellular death domain
- (C) BCL-2 is a proapoptotic protein
- (D) Entry of cytochrome c into mitochondria is a critical step
7 >>All of the following are proapoptic proteins, except: ?
- (A) Bax
- (B) Bid
- (C) Bcl-2
- (D) Bak
8 >>All of the following are anti-apoptotic proteins, except: ?
- (A) Bcl-X1
- (B) Bcl-2
- (C) Bcl-6
- (D) None of the above
9 >>Which of the following statements is not true regarding transcription factors? ?
- (A) Contains DNA binding and activation domain
- (B) Helix-loop-helix is a DNA-binding domain
- (C) c-abl gene translocation in CML, is an example
- (D) They regulate gene expression by regulating the transcription of specific genes
10 >>Which one of these statements is not true regarding cell adhesion molecules? ?
- (A) Chemokines are a major family
- (B) They include the immunoglobulin superfamily
- (C) They are important in the spread and localization of tumor cells
- (D) Integrins can bind cells to extracellular matrix
11 >>Which one of these molecules does not have a role in the transduction pathway of growth factors? ?
- (A) p 53
- (B) RAS
- (C) STAT
- (D) JAK
12 >>Which of the following statement is not true regarding clonal abnormality in cytogenetic analysis? ?
- (A) 2 cells with translocation, deletions or inversions signifies abnormal chromosome
- (B) 1 cell showing loss of chromosome
- (C) Single cell with recurring structural abnormality
- (D) 2 cells with gain of same chromosome
13 >>All of the following are major cell cycle check points, except: ?
- (A) DNA damage check point
- (B) The spindle check point
- (C) The spindle pole body duplication check point
- (D) RNA damage check point
14 >>A 29 year old woman was found to have a Hb of 7.8 gm/dL with reticulocyte count of 0.8%. PS showed microcytic hypochronic anemia. Hb A2 and Hb F levels were 2.4% and 1.3% respectively. Serum iron and TIBC were 15 mgm/dL and 420 mgm/dL repectively. The likely diagnosis is: ?
- (A) IDA
- (B) ? thalassemia minor
- (C) Sideroblastic anemia
- (D) Anemia of chronic inflammation
15 >>A child presented with microcytic hypochromic anemia with normal levels of RBC protoporphyrin. Most likely diagnosis is: ?
- (A) Lead toxicity
- (B) IDA
- (C) Thalassemia
- (D) Anemia of chronic inflammation
16 >>Which of the following test is best suited for community based screening programme for identifying iron deficiency? ?
- (A) Serum ferritin
- (B) Red cell protoporphyrin level
- (C) Serum iron
- (D) TIBC
17 >>Which of the following test is best in differentiating between anemia of chronic inflammation and IDA? ?
- (A) Serum ferritin
- (B) Serum transferrin receptor
- (C) TIBC
- (D) Transferrin saturation
18 >>Elevated serum ferritin, serum iron and percentage transferring saturation are most consistent with diagnosis of: ?
- (A) IDA
- (B) Hemochromatosis
- (C) Anemia of chronic inflammation
- (D) Lead poisioning
19 >>Which of the following is earliest recognizable change in RBC morphology in case of iron deficiency? ?
- (A) Hypochromia
- (B) Anisocytosis
- (C) Target cells
- (D) Poikilocytosis
20 >>All of the following are causes of iron deficiency anemia, except: ?
- (A) Chronic renal failure
- (B) Celiac sprue
- (C) Hookworm
- (D) Carcinoma colon
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