Hematology Quiz | Practice MCQ #mcq.ImBooz

• (A) Microvasculature is commonly involved
• (B) Chronic transfusion does not help much
• (C) Cognitive impairment is not seen
• (D) Transcranial Doppler is helpful

Check AnswerSolution[D]:-Transcranial Doppler is helpful

• (A) Is associated with normal growth and life expectancy
• (B) The ratio of HbA to HbS is 50:50
• (C) Impaired urine-concentrating ability and haematuria can occur
• (D) Splenic infarction is possible at very high altitudes

Check AnswerSolution[B]:-The ratio of HbA to HbS is 50:50

• (A) Can distinguish sickle cell trait from sickle cell anaemia
• (B) Can be used for primary diagnosis of HbSS
• (C) Can quantify HbS
• (D) None of the above

Check AnswerSolution[D]:-None of the above

• (A) Acute chest syndrome
• (B) Acute painful crises
• (C) Leg ulcers
• (D) All of the above

Check AnswerSolution[C]:-Leg ulcers

• (A) DNA replication occurs in G1 phase
• (B) The normal cell cycle is G1-S-G2-M
• (C) Cdk phosphorylates the protein targets
• (D) Cyclin proteins are formed during specific phases

Check AnswerSolution[A]:-DNA replication occurs in G1 phase

• (A) Caspases are the ultimate effectors of apoptosis
• (B) FAS and TNF-R have an extracellular death domain
• (C) BCL-2 is a proapoptotic protein
• (D) Entry of cytochrome c into mitochondria is a critical step

Check AnswerSolution[A]:-Caspases are the ultimate effectors of apoptosis

• (A) Bax
• (B) Bid
• (C) Bcl-2
• (D) Bak

Check AnswerSolution[C]:-Bcl-2

• (A) Bcl-X1
• (B) Bcl-2
• (C) Bcl-6
• (D) None of the above

Check AnswerSolution[C]:-Bcl-6 is a sequence-specific repressor of transcription and is shown to modulate the STAT-dependant IL-4 response of B cells. Also interacts with several corepressor complexes to inhibit transcription. Involved in pathogenesis of various lymphoma, e.g. DLBCL, Burkitt lymphoma, follicular lymphoma and NLPHL.

• (A) Contains DNA binding and activation domain
• (B) Helix-loop-helix is a DNA-binding domain
• (C) c-abl gene translocation in CML, is an example
• (D) They regulate gene expression by regulating the transcription of specific genes

Check AnswerSolution[C]:-c-abl gene translocation in CML, is an example

• (A) Chemokines are a major family
• (B) They include the immunoglobulin superfamily
• (C) They are important in the spread and localization of tumor cells
• (D) Integrins can bind cells to extracellular matrix

Check AnswerSolution[A]:-Chemokines are a major family

• (A) p 53
• (B) RAS
• (C) STAT
• (D) JAK

Check AnswerSolution[A]:-p 53

• (A) 2 cells with translocation, deletions or inversions signifies abnormal chromosome
• (B) 1 cell showing loss of chromosome
• (C) Single cell with recurring structural abnormality
• (D) 2 cells with gain of same chromosome

Check AnswerSolution[B]:-The observation of at least 2 cells with the the same structural rearrangements (e.g. translocation, deletions, inversions and gain of same chromosome, or 3 cells showing loss of same chromosome) is considered evidence for the presence of an abnormal clone. However, one cell with a normal karyotype is considered evidence for the presence of a normal cell line. Patients whose cells show no alteration or non-clonal (single cell) abnormalities are considered to be normal. However a single cell characterized by a recurring structural abnormality is an exception to this.

• (A) DNA damage check point
• (B) The spindle check point
• (C) The spindle pole body duplication check point
• (D) RNA damage check point

Check AnswerSolution[D]:-A number of surveillance system (check points) control the cell cycle and interrupts its progression when DNA damage occurs or when the cells have failed to complete a necessary event. Three major cell cycle checkpoints have been discerned. The DNA damage checkpoints, the spindle checkpoint and the spindle pole body duplication checkpoint. Cancer cells are often missing one or more checkpoints, which facilities a greater rate of genomic evolution.

• (A) IDA
• (B) ? thalassemia minor
• (C) Sideroblastic anemia
• (D) Anemia of chronic inflammation

Check AnswerSolution[A]:-IDA

• (A) Lead toxicity
• (B) IDA
• (C) Thalassemia
• (D) Anemia of chronic inflammation

Check AnswerSolution[C]:-Both lead toxicity and IDA have microcytic hypochromic blood pictures and the red cell protoporphyrin levels are elevated in both conditions. RBC protoporphyrin (esp. zinc protoporphyrin) in disorders of heme synthesis including IDA, lead poisioning, sideroblastic anemia, anemia due to inflammation or malignancy. (526, William’s)

• (A) Serum ferritin
• (B) Red cell protoporphyrin level
• (C) Serum iron
• (D) TIBC

Check AnswerSolution[B]:-Red cell protoporphyrin level

• (A) Serum ferritin
• (B) Serum transferrin receptor
• (C) TIBC
• (D) Transferrin saturation

Check AnswerSolution[B]:-which can be falsely elevated. It has been shown by many studies that Transferrin Receptor/log of ferritin is more accurate in differentiating between IDA and ACD (Blood 89: 1052, 1997). The gold standard for IDA is absent stainable iron in BM aspirate but it has drawbacks for example it is invasive procedure and difficulty in differentiating from artefacts within macrophages. Iron in bone marrow aspirate (stained with Prussian blue) can be found as storage iron in cytoplasm of macrophages or as functional iron (siderosome) in nucleated red cell (sideroblast). Approximately 1/3rd of nucleated red cells contain 1-4 fine blue inclusion bodies (siderosome). Both sideroblast and macrophage iron is increased in ACD.

• (A) IDA
• (B) Hemochromatosis
• (C) Anemia of chronic inflammation
• (D) Lead poisioning

Check AnswerSolution[B]:-Hemochromatosis is the increase in tissue iron with associated tissue damage and is characterized by bronzing of skin, cirrhosis and diabetes. Hemosiderosis is increase in tissue iron without tissue damage. Primary hemochromatosis is most commonly due to HFE gene mutation. It is associated with increased % saturation, S. iron and S. ferritin. ACD will have low S. iron and IDA will have all 3 parameters low.

• (A) Hypochromia
• (B) Anisocytosis
• (C) Target cells
• (D) Poikilocytosis

Check AnswerSolution[B]:-Anisocytosis

• (A) Chronic renal failure
• (B) Celiac sprue
• (C) Hookworm
• (D) Carcinoma colon

Check AnswerSolution[A]:-Chronic renal failure