1 >>Antibody screening showed all panel cells positive reaction and subsequent extended panels used to identify the antibody gave positive reactions with all cells. The possible cause(s) of this are: ?
- (A) Presence of autoantibody
- (B) Alloantibody against a high frequency antigen
- (C) Presence of multiple allo-antibodies
- (D) All of the above
2 >>A patient is a case of acute promyelocytic leukemia on chemotherapy with DIC with a Hb of 7.0 gm/dl requiring blood transfusion. A red cell unit is removed from storage and should be transfused: ?
- (A) Within 30 minutes of removal from cold storage
- (B) Within 2 hours or when the unit has come to room temperature
- (C) After warming to 37°C
- (D) Within 1 hour of removal from cold storage
3 >>The same unit must be completely transfused within: ?
- (A) 30 minutes
- (B) 4 hours
- (C) 6 hours
- (D) 8 hours
4 >>Transfusion Related Acute Lung Injury (TRALI) can be caused by the transfusion of: ?
- (A) Red cells
- (B) Plasma
- (C) Platelets
- (D) All of the above
5 >>Eight years old female patient presented with marked anemia 6.1 gm/dl and dark urine following recent transfusion. She has undergone an allogenic PBSCT 6 months prior for AML and is having active acute GVHD for which she is receiving weekly red cell and SDP transfusion. The transplant was a major ABO mismatch with the donor A and recipient O. The DAT was weekly positive and eluate was positive against A1 cells at 37 �C by indirect AHG. Microspherocytes were present in the blood film. There were no mixed field reactions in the patient’s blood group. What is the most likely cause of his dark urine? ?
- (A) Hemolysis due to anti-A in donor red cells
- (B) Hemolysis due to anti-A in donor platelets
- (C) Hemolysis due to AIHA
- (D) Hemolysis due to associated GVHD
6 >>Coomb’s cross-match should be done in all of the following, except: ?
- (A) Recipient having Rh -ve blood froup
- (B) Neonatal transfusion
- (C) Post allogenic BMT recipient patient
- (D) AIHA
7 >>A young teenager with diagnosis of sickle cell disease admitted with acute chest syndrome and his Hb falls from 8 to 5.5 gm/dl for which he was given 3 units of packed RBCs urgently. His Hb improved to 9.0 gm/dL but after 1 week he was found to have blackish urine, pain in back and with jaundice. His LDH was 1000 mg/dL, reticulocyte were 1% with DCT being negative and no atypical antibody found. All of the following can be done, except: ?
- (A) IVIg
- (B) Erythropoietin
- (C) Corticosteroids
- (D) All of the above
8 >>Result of a pregnant lady Rh-D typing and done using an Anti-D reagent potentiating agent PEG are patient-strong and control-weak. The next course of action will be: ?
- (A) Report as D-positive
- (B) Report as D-negative
- (C) Perform a DCT and repeat D-typing using different technique
- (D) Perform a DCT and if it is positive report as D-negative
9 >>Administration of 500 IU of anti-D is sufficient prophylaxis for future hemolytic disease of the newborn will cover a bleed of: ?
- (A) 2 ml
- (B) 4 ml
- (C) 6 ml
- (D) 8 ml
10 >>Irradiation of blood will: ?
- (A) Decrease potassium leakage from red cells
- (B) Not required for transfusions from close relatives
- (C) Not required for leukodepleted RBCs
- (D) Reduces the shelf life of red cells
11 >>An elderly gentleman, a known case of CLL (Binet Stage A) for which he never received any treatment. He was brought to casualty with Hb-of 5.0 gm/dL. Cross matching was difficult because of DCT and ICT being positive against all panel cells. RBC morphology was normal with normal bilirubin and LDH. What is the most appropriate transfusion product? ?
- (A) Irradiated packed RBC
- (B) ABO/Rh/matched, “least incompatible” packed red cells
- (C) Washed packed RBCs
- (D) HLA matched RBCs
12 >>A patient with sickle cell anemia should avoid the following: ?
- (A) Swimming
- (B) Dehydration
- (C) Pneumococoal immunization
- (D) Early antibiotics for respiratory infection
13 >>Which of the following may constitute high-risk during surgery? ?
- (A) ?-Thalasemia minor
- (B) Hb S homozygous
- (C) Hb D Punjab
- (D) Hb E trait
14 >>A patient of sickle cell disease presented with priapism. Which of the following is contraindicated? ?
- (A) Hydralazine
- (B) Atenolol
- (C) Shunt surgery
- (D) Etilefrine
15 >>In a sickle cell disease patient to cause vaso-occlusive crisis, Hb S level should be: ?
- (A) 0.2
- (B) 0.4
- (C) 0.6
- (D) 0.3
16 >>The least severe form of sickle cell disease is: ?
- (A) Hb SS
- (B) Hb S?0
- (C) Hb S?+
- (D) SCD with hereditary persistence of fetal hemoglobin (S/HPFH)
17 >>The least common cause of death in adult with sickle cell disease is: ?
- (A) Pulmonary hypertension
- (B) Sudden death of unknown etiology
- (C) Renal failure
- (D) Myocardial infarction
18 >>Which is least implicated in the pathophysiology of sickle cell disease? ?
- (A) Neutrophils
- (B) Nitric oxide
- (C) Platelets and coagulation factors
- (D) Free hemoglobin
19 >>Events which precipitate veno-occlusive crises are: ?
- (A) Dehydration
- (B) Infection
- (C) Extreme temperature
- (D) All of the above
20 >>True regarding acute chest syndrome is: ?
- (A) Pulmonary infiltrates are seen
- (B) Risk of mortality increases
- (C) Hydroxyurea is indicated
- (D) Pulmonary hypertension is an important cause
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