Hematology Quiz | Practice MCQ #mcq.ImBooz

• (A) Osmocytometer
• (B) Spherocytometer
• (C) Ektacytometer
• (D) Viscometer

Check AnswerSolution[C]:-After incubation at 37°C for 24 hours, HS red cells loose membrane surface area more readily because their membranes are leaky and unstable. Basically incubation accentuates the defect in HS.

• (A) Band 3
• (B) Ankyrin
• (C) Protein 4.2
• (D) Protein 4.1

Check AnswerSolution[A]:-Band 3

• (A) Increase in surface area due to lipid gain
• (B) Decrease in surface area due to lipid loss
• (C) Weakening of skeletal protein
• (D) All of the above

Check AnswerSolution[A]:-Increase in surface area due to lipid gain

• (A) Horizontal
• (B) Vertical
• (C) Both
• (D) Variable connections

Check AnswerSolution[B]:-Vertical

• (A) Neutropenia
• (B) Thrombocytopenia
• (C) Toxic cells
• (D) Target cells

Check AnswerSolution[C]:-Toxic cells

• (A) Decreased osmotic fragility
• (B) Increased osmotic fragility
• (C) Normal osmotic fragility
• (D) None of the above

Check AnswerSolution[A]:-Decreased osmotic fragility

• (A) Iron
• (B) DNA
• (C) RNA
• (D) Ribosomal proteins

Check AnswerSolution[A]:-Iron

• (A) Iron
• (B) DNA
• (C) RNA
• (D) Protein

Check AnswerSolution[B]:-DNA

• (A) Spectrin and ankryin combined defect is the most common finding in HS
• (B) Glycophorin is the most abundant integral protein followed by band-3
• (C) Lipid compose 30% of red cell membrane mass
• (D) Alteration in serum lipid concentration in influence the red cell membrane

Check AnswerSolution[C]:-Lipids compose 50-60% of red cell membrane. Mass alterations in the serum lipid concentrations can make changes in RBC membrane and leads to alteration in RBC shape, e.g. dyslipidemia and in alcoholic liver disease (altered/loss of lipoproteins).

• (A) Inherited deficiency of CD 55
• (B) Inherited deficiency of CD 59
• (C) Inherited deficiency of CD 55 and CD 59 both
• (D) Acquired deficiency of CD 55

Check AnswerSolution[A]:-Inab phenotype of RBC is the congenital deficiency of CD 55 on RBC that is why to diagnose PNH it is always recommended to test for at least 2 GPI anchor protein together (viz. CD55 and CD59). There is a congenital deficiency of CD59.

• (A) Packed red blood cells
• (B) Platelets
• (C) Fresh frozen plasma
• (D) Cryoprecipitate

Check AnswerSolution[B]:-Both whole blood derived and apheresis platelet concentrates can be stored for 5 days at 20-24°C. Storage container should be of plastic material that allows adequate diffusion of oxygen to meet the cells metabolic needs and the platelet concentrates must be agitated during storage.Red cells are preserved by either liquid storage at 4°C or frozen storage with various cryoprotective agents at-80°C.FFP and cryoprecipitates are stored at-80°C.

• (A) Skin rash
• (B) Diarrhea
• (C) Jaundice
• (D) Pancytopenia

Check AnswerSolution[D]:-A rare complication of transfusion is TA-GVHD, which develops after the engraftment of allogenic lymphocytes that attack the recipients tissue. It begins within 3-30 days after transfusion. It occurs d/t to transfusions from close relatives or other genetically matched donors are administered to severely immune-compromised recipients (may occur in immune- competent hosts also). It presents as maculopapular rash, fever, watery diarrhea, liver dysfunction and marrow failure. There is approximately 90% mortality rate.

• (A) Usually develops 1 week after transfusion
• (B) Most patient’s have anti-HPA-1a antibodies
• (C) Treatment of choice is IVIg
• (D) Severe thrombocytopenia is rare

Check AnswerSolution[D]:-Severe thrombocytopenia is rare

• (A) CMV infection
• (B) HCV transmission
• (C) Febrile non-hemolytic transfusion reaction
• (D) Reduce the risk of alloimmunization

Check AnswerSolution[B]:-HCV transmission

• (A) VWF
• (B) Factor VIII
• (C) Fibrinogen
• (D) Factor IX

Check AnswerSolution[D]:-Cryoprecipitate contain factor VIII, fibrinogen, fibronectin, VWF and factor XIII

• (A) FFP
• (B) Granulocytes
• (C) RBCs
• (D) Platelets

Check AnswerSolution[A]:-FFP

• (A) Detects agglutination of antibody coated red cells
• (B) It may detect complements attached to red cell surface
• (C) It is used for cross matching
• (D) It is positive in hemolytic disease of newborn because of Rh incompatibility

Check AnswerSolution[C]:-It is used for cross matching

• (A) Hepatitis C antibody
• (B) Hepatitis B
• (C) Malaria
• (D) Typhoid

Check AnswerSolution[D]:-Typhoid

• (A) Group O RBC to Group A recipient
• (B) Group O RBC to Group AB recipient
• (C) Rh +ve RBC to Rh -ve recipient
• (D) Group A RBC to group O recipient

Check AnswerSolution[D]:-Group A RBC to group O recipient

• (A) Invasion by P. falciparum
• (B) Red cell urea transporter
• (C) Maintenance of membrane integrity
• (D) Invasion by P. vivax

Check AnswerSolution[D]:-Invasion by P. vivax