1 >>Which of the following is not true about Wiskott-Aldrich syndrome? ?
- (A) Thrombocytopenia
- (B) Autosomal recessive
- (C) Small platelets
- (D) Eczema
2 >>Thrombocytopenia is seen in all except: ?
- (A) HSP
- (B) DIC
- (C) TTP
- (D) Leukemia
3 >>Immune destruction of platelets is seen in all, except: ?
- (A) CLL
- (B) HIV
- (C) SLE
- (D) All of the above
4 >>All of the following can be seen in TTP, except: ?
- (A) Micro-angiopathic hemolytic anemia
- (B) Thrombocytopenia
- (C) Prolingation of both PT and APTT
- (D) Presence of fever
5 >>A 25 years old girl is brought to the emergency department in the state of altered sensorium with high grade fever. Investigation revealed anemia, thrombocytopenia with fragmented red cells on peripheral blood smear examination. CT-brain is normal and a serum creatinine is 3.0 mg/dl. PT/APTT/TT are normal. Which of the following is the most effective treatment? ?
- (A) Plasma exchange therapy
- (B) Steriods with IVIg
- (C) Platelet transfusion
- (D) Broad-spectrum IV antibiotics
6 >>All of the following are used in the treatment of TTP, except: ?
- (A) Corticosteriods
- (B) Plasma exchange therapy
- (C) Cryosupernatant transfusion
- (D) Platelet transfusion
7 >>A 25 years old healthy woman has delivered a baby who after birth, is drowsy and found to have a cerebral hemorrhage. Her platelet count is 21000/mm3 and the maternal platelet count is 1,30,000/ ?
- (A) mm3. Maternal serum will most likely show:
- (B) Antibodies to HIV
- (C) Anti HPA-1a antibodies
- (D) Platelet auto antibodies
8 >>A young pregnant lady is registered in ante-natal clinic and found to be having blood group B Rh D positive. In previous pregnancy she was grouped as BRhD negative and has documenting evidence of her blood group: ?
- (A) Laboratory error
- (B) Weak/Partial Rh D group
- (C) Rh null phenotype
- (D) Presence of anti-D in her serum
9 >>A neonate is found to have petechial spots all over body with gum bleeding and hematuria after a full term normal vaginal delivery. CBC showing normal Hb and WBC with platelet count of 10,000/mm3.Peripheral smear examination is normal. Mother did not have any major problem during pregnancy and has no h/o any autoimmune thrombocytopenia or other autoimmune disease and having a platelet count of 1,70,000/mm3. What urgently to be done? ?
- (A) Platelet administration (random)
- (B) Administer mother’s platelet
- (C) Steroids
- (D) High dose IVIg
10 >>An elderly gentleman develops purpura all over body 7 days after anterior resection for carcinoma colon. He was found to have platelet count of 10,000 with normal WBC and Hb. Coagulation was normal.He was given 4 units of packed RBCs during surgery and was on LMWH prophylaxis for VTE. What is to be done? ?
- (A) Platelet transfusion
- (B) Corticosteroids
- (C) High dose IVIg
- (D) Stop heparin and start on Warfarin/Fondaporinux
11 >>A young lady presented with micro-angiopathic hemolytic anemia, thrombocytopenia and reduced level of consciousness. Her ADAMTS level was low and was diagnosed as TTP. She was given plasma exchange to which she responded and then relapses after 1 year.What is the treatment option now? ?
- (A) Plasma exchange
- (B) Plasma exchange plus rituximab
- (C) Plasma exchange plug splenectomy
- (D) High dose steroids
12 >>A young lady presented with purpura all over body with gum bleeding and having platelet count of 15,000/mm3. She was given steroid to which she responded and again the platelets dropped to 40,000/mm3 after tapering of steroids was done. At this time she was found to be HIV positive. What treatment should be given to this patient? ?
- (A) Anti-D
- (B) High dose IVIg
- (C) Highly active anti-retroviral therapy (HAART)
- (D) No treatment
13 >>Which of the following can be given safely in pregnancy? ?
- (A) Imatinib
- (B) Heparin
- (C) Warfarin
- (D) Thalidomide
14 >>Five days after starting warfarin therapy in a patient of atrial fibrillation the 60 year old man returns to his physician complaining of large patches of discolored stain over his gluteal region and legs.This complication is most likely the result of: ?
- (A) Antithrombin III deficiency
- (B) Protein C deficiency
- (C) Drug allergy
- (D) Very high INR
15 >>All of the following can cause both arterial and venous thrombosis, except: ?
- (A) APLA syndrome
- (B) Hyper homocysteinemia
- (C) Protein C deficiency
- (D) Polycythemia vera
16 >>Commonest inherited cause of thrombosis in Caucasians is: ?
- (A) Protein S deficiency
- (B) Factor V leiden mutation
- (C) Anti thrombin III deficiency
- (D) Protein C deficiency
17 >>Which of the following is a major risk factor for venous thrombosis? ?
- (A) Smoking
- (B) High cholesterol
- (C) Hypertension
- (D) Diabetes mellitus
18 >>Which of the following is not a risk factor for arterial thrombosis? ?
- (A) Diabetes mellitus
- (B) Male sex
- (C) Smoking
- (D) Hypohomocysteinemia
19 >>Which one of the following statement is true regarding factor V Leiden gene mutation? ?
- (A) In Caucasians the incidence of factor V Leiden is 5%
- (B) Individuals have an increased risk of bleeding
- (C) Homozgous or heterozygous state carries the same risk
- (D) Factor V Leiden mutation is the most common cause of APC resistance
20 >>Which of the following statement is not true? ?
- (A) Antithrombin III deficiency is sex linked
- (B) Mucinous adenocarcinomas are more prone for DIC
- (C) Protein C deficiency can develop coumadin induced skin necrosis when started without heparin
- (D) Obesity is a risk factor for thrombosis in postoperative patient